Prevalence of Metabolic Syndrome in Reproductive-Aged Polycystic Ovary Syndrome Thai Women
Suchada Indhavivadhana MD*, Thanyarat Wongwananuruk MD*, Manee Rattanachaiyanont MD*, Kitirat Techatraisak MD*, Pichai Leerasiri MD*, Prasong Tanmahasamut MD*, Monrudee Popijan BNS*
Affiliation : * Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Objective : To determine the prevalence of metabolic syndrome (MS) in reproductive-aged polycystic ovary syndrome (PCOS)
Thai women.
Material and Method: A Cross sectional study was done at the Gynecologic Endocrinology Unit, Department of Obstetrics
and Gynecology, Faculty of Medicine Siriraj Hospital of 250 PCOS Thai women who were diagnosed using Revised Rotterdam
2003 criteria, and who did not take medications affecting sex hormones or lipid metabolism, and attended the Gynecologic
Endocrinology Unit between May 2007 and January 2009. Patents were interviewed and examined for weight, height, waist
circumference, and blood pressure. Venous blood sample of each patient was drawn after 12-hour fasting. Prevalence of MS
determined using the definitions of National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III),
International Diabetes Federation (IDF), and National Heart Lung and Blood Institutes/American Heart Association (NHLBI/
AHA).
Results : Mean + SD of age, body mass index (BMI), and waist circumference (WC) were 25.4 + 5.8 years, 26.2 + 7.6 kg/M2,
and 82.3 + 16.3 cm, respectively. Prevalence of MS by the definitions of NCEP ATP III, IDF, and NHLBI/AHA was 18.0%,
21.2%, and 21.2%, respectively. Of non-MS women, > 40% already had one to two criteria of IDF definition. Among MS
women, 100% had central obesity, 50.9% had high blood pressure, 28.3% had impaired fasting blood glucose, 62.3% had
hypertriglyceridemia, and 92.5% had high-density lipoprotein cholesterol < 50 mg/dL. The prevalence of MS increased from
10.3% in women aged < 20 years to 50.0% in those aged > 40 years (p of trend = 0.003), and from 0.0% in women with BMI
< 23 kg/M2 to 54.5% in those with BMI > 30 kg/M2 (p of trend < 0.001).
Conclusion : The prevalence of MS in reproductive-aged PCOS Thai women was 18.0% by NCEP ATP III and 21.2% by IDF
and NHLBI/AHA. The prevalence varies only little with definitions of diagnostic criteria. The prevalence increases with age
and body mass index. Slightly more than 40% of the non-MS PCOS Thai women already had one to two criteria of MS.
Keywords : Metabolic syndrome, PCOS, Polycystic ovary syndrome, Thai
