Isolation and Antimicrobial Susceptibility Testing of Haemophilus influenzae in a Tertiary Care Hospital, a 6-Year Study (2016 to 2021)
Piriyaporn Chongtrakool¹, Patcharee Choochur², Huttaya Thuncharoon², Maytinee Srifuengfung¹, Boonta Sawatdijaroongrat², Chalermsri Pummangura³, Dararat Samretwit³, Somporn Srifuengfung³
Affiliation : ¹ Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand ² Microbiology Laboratory, Taksin Hospital, Bangkok, Thailand ³ Faculty of Pharmacy, Siam University, Petchkasem Road, Bangkok, Thailand
Objective: To determine the prevalence and antimicrobial susceptibility of Haemophilus influenzae at Taksin Hospital.
Materials and Methods: The susceptibilities of clinical isolates to six antimicrobial agents, ampicillin (AP), cefuroxime (CXM), cefotaxime (CTX), ciprofloxacin (CIP), trimethoprim-sulfamethoxazole (SXT), and meropenem (MEM), between 2016 and 2021 were evaluated by the standard disk diffusion method.
Results: One hundred thirty-eight H. influenzae clinical isolates were found in different patients. There were 63.04% male patients. The ages of patients ranged from two months to 93 years old (mean±SD: 65.67±20.58). H. influenzae was mostly found in patients older than 50 (60.14%) years old. In children, H. influenzae was mostly found in patients younger than 1 to 10 (16.67%) years old. Unduplicated H. influenzae from different patients were isolated from the sputum (71.01%), blood (11.59%), pus from eyes (10.14%), and urethra (2.90%). H. influenzae demonstrated 100% susceptibility to CTX, CIP, and MEM, but less susceptibility to CXM (93.48%), AP (49.28%), and SXT (53.62%).
Conclusion: The present study results suggested the importance of monitoring the prevalence of H. influenzae at a hospital in Bangkok. The antibiogram of susceptibility helps provide guidelines for clinician to consider empirical treatment.
Received 19 January 2022 | Revised 2 March 2022 | Accepted 15 March 2022
DOI: 10.35755/jmedassocthai.2022.04.13296
Keywords : Haemophilus influenzae; Drug resistance, Thailand
