Frequency and Clinical Course of Invasive Pneumococcal Disease Caused by Penicillin-Resistant and Penicillin-Sensitive Streptococcus pneumoniae in Thai Children
Natawan Siripongpreeda MD*, Weerawan Hattasingh MD**, Patcharin Amornvipas MD**, Boonchuay Eampokalap MSc*, Supachat Sakoolgnam MD***, Chitsanu Pancharoen MD**, Usa Thisyakorn MD**
Affiliation : * Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand ** Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand *** Paholponpayuhasena Hospital, Kanchanaburi, Thailand
Objective : This study assessed clinical differences between invasive pneumococcal disease (IPD) caused by penicillin-
resistant and penicillin-sensitive Streptococcus pneumoniae.
Material and Method: Patients with IPD confirmed during January 1996-December 2007 at three hospitals were included.
Clinical characteristics and outcomes were compared between patients infected with penicillin-resistant Streptococcus
pneumoniae (PRSP) and penicillin-sensitive Streptococcus pneumoniae (PSSP).
Results : Sixty-nine patients with IPD were identified during the study period, 20 (29%) of whom were infected with PRSP and
49 (71%) with PSSP. Sex, mean age, underlying diseases and seasonal variation did not differ statistically between the two
groups. No significant differences were identified in clinical course as measured by time until defervescence, duration of
hospitalization and clinical outcome. Minimum inhibitory concentrations (MIC) for other antibiotics were determined; 20%
and 10% of PRSP isolates were nonsusceptible to cephalosporins and meropenem, respectively, but all isolates were sensitive
to vancomycin.
Conclusion : There were no significant differences identified in the clinical epidemiology of IPD cases caused by PRSP and
PSSP.
Keywords : Invasive pneumococcal disease (IPD), Penicillin-sensitive Streptococcus pneumoniae (PSSP), Penicillin-resistant Streptococcus pneumoniae (PRSP)
