A Comparative Study of Bone Mineral Density between Premenopausal Women with Hyperthyroidism and Healthy Premenopausal Women
Trirat Boonya-ussadorn MD*, Boondharika Punkaew MD*, Narongchai Sriassawaamorn MD*
Affiliation : * Division of Nuclear Medicine, Department of Radiology, Phramongkutklao Hospital, Bangkok, Thailand
Objective : To compare bone mineral density (BMD) of the lumbar spine (L1-L4), total hip (TH), and femoral neck (FN)
analyzed by Dual Energy X-ray Absorptiometry (DXA) in premenopausal women with hyperthyroidism and in healthy
premenopausal women.
Material and Method: Cross-sectional study included 49 premenopausal women with hyperthyroidism and 49 healthy
premenopausal women. Age, weight and body mass index (BMI) were comparable in both groups. All subjects had a BMD
measurement by DXA in the region of L1-L4, TH and FN and the unpaired t-test was used to analyze.
Results : The mean BMD of premenopausal women with hyperthyroidism at L1-L4, TH and FN was 0.928, 0.838 and 0.774
g/cm2, which were lower than those of healthy premenopausal women; 0.991, 0.917 and 0.832 g/cm2
, respectively (p-value is
less than 0.05). Time interval that had elapsed for active hyperthyroidism was not associated with the decrease of BMD at L1-
L4, TH and FN in hyperthyroid women.
Conclusion : The BMD of L1-L4, TH and FN in premenopausal women with hyperthyroidism were significantly lower than
those of healthy premenopausal women. Therefore, overt hyperthyroidism could be associated with bone loss and may be a
risk factor for the development of osteoporosis. However, time interval of active hyperthyroidism was not related to the
decrease of BMD in hyperthyroid women.
Keywords : Bone mineral density, Premenopausal women, Hyperthyroidism, Dual energy X-ray absorptiometry (DXA)
