Prevalence of Aspirin Resistance in Stroke Patients in Phramongkutklao Hospital
Samart Nidhinandana MD*, Siriprang Changchit MD **
Affiliation : * Department of Neurology and Psychiatry, Phramongkutklao Hospital, Bangkok, Thailand ** Neurologic Division,Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand
Objective : To study the prevalence of aspirin resistance in cerebrovascular disease patients in Phramongutklao hospital .
Material and Method: The acute ischemic and stable stroke patients who received aspirin at least 60 mg, at least 7 days and
the last dose of aspirin at least 24 hours before blood test for platelet aggregation. ADP and Collagen were used as platelet
aggregator.
Results : During July 2007- December 2008 , 141 cases of ischemic stroke were enrolled. “Aspirin resistant” was defined as
mean aggregation more than 60% both ADP and Collagen. “Aspirin semi-responder” was mean aggregation less than 60%
for ADP or Collagen.
Conclusion : Prevalence of aspirin resistance in Phramonkutklao hospital is 56 % (79/141), and there are relationship
between aspirin resistance and timing in the first episode of stroke.
Keywords : Aspirin resistance, Ischemic stroke
