Comparison of Changes of Body Water Measured by Using Bioelectrical Impedance Analysis between Lercanidipine and Amlodipine Therapy in Hypertensive Outpatients
Nakarin Sansanayudh MD*, Supakit Wongwiwatthananukit MD**, Siriluck Veerayuthvilai MD***
Affiliation : * Cardiology unit, Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, Thailand ** College of Pharmacy, University of Hawaii at Hilo, United State of America *** Department of Pharmacology, Somdejprapinklao Hospital, Bangkok, Thailand
Objective : To compare changes of body water measured by using bioelectrical impedance analysis (BIA),
between lercanidipine and amlodipine therapy.
Material and Method: This is a prospective randomized open-label study in hypertensive outpatients. Eighty
patients were randomized into two groups; 1) amlodipine 5 mg/d and 2) lercanidipine 10 mg/d. Patients were
assessed for changes in total body water (TBW), extracellular water (ECW) and intracellular water (ICW) at
week 4 and 8 after treatment.
Results : At baseline body water in both groups were similar. After treatment, both groups did not have
significant changes in body water from baseline. Seven patients in amlodipine group (17.5%) and none of
lercanidipine group developed edema; p = 0.012. Among those seven patients, TBW, ECW and ICW all
increased significantly from baseline.
Conclusion : BIA did not detected changes of body water in most patients. However, in patients who developed
edema, TBW, ECW and ICW significantly increased from baseline with the greatest changes seen in extracellular
compartment.
Keywords : Lercanidipine, Amlodipine, Body water, Peripheral edema, Hypertension, Bioelectrical impedance analysis
