Tramadol Suppository versus Placebo for the Relief of Perineal Pain after Perineorrhaphy: A Randomized Controlled Trial in Thailand
Thanarat Srimaekarat MD*
Affiliation : * Department of Obstetrics and Gynecology, Trang Regional Hospital, Trang, Thailand
Objective : This randomized double-blinded control trial was conducted to compare the effectiveness of tramodol and placebo
rectal suppository for the management of postpartum perineal pain after perineorrhaphy.
Material and Method: One hundred women who gave birth vaginally with episiotomy and a second- or third-degree tear,
were randomly assign to receive two tablets of tramadol 50 mg or two tablets of placebo, the pill were physically similar to the
real drug. Pain ratings were recorded immediately after perineorrhaphy, 30 minutes, and 1, 2, 6, 12 and 24 hours after first
dose on a 10-cm visual analogue scale. Side effects and overall opinion were assessed.
Results : Tramadol and placebo had no statistical significances in analgesic properties, assessed by the means of pain rating
at the different time intervals. There were no serious adverse events reported.
Conclusion : No differences were found in between Tramadol and placebo in relief perineal pain after perineorrhaphy.
Keywords : Tramadol, Rectal suppository, Perineal pain, Perineorrhaphy
