Sensitivity and Specificity of Modified 100-G Oral Glucose Tolerance Tests for Diagnosis of Gestational Diabetes Mellitus
Jarunee Hansarikit MD*, Saknan Manotaya MD*
Affiliation : * Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Objective : To study the sensitivity and specificity of the modified 100-g oral glucose tolerance test for diagnosis of gestational
diabetes mellitus (GDM).
Material and Method: Medical records of pregnant women attending the antenatal clinic of King Chulalongkorn Memorial
Hospital, Thailand, who underwent a 100-g oral glucose tolerance test (OGTT) during March 2004 to September 2009, were
retrospectively reviewed. Three modified criteria were proposed for diagnosis of GDM. The screening efficacy of the modified
criteria were assessed, using the National Diabetes Data Group (NDDG) criterion as gold standard.
Results : A total of 729 records were reviewed, 511 were included for analysis. Using the NDDG criterion as the gold
standard, the modified II criterion has the highest sensitivity of 96.8%, and the highest accuracy of 90.8%. The modified II
criterion can detect the same proportion of maternal and neonatal complications, compared to the NDDG criterion.
Conclusion : The modified II criterion, using the fasting plasma glucose and 2-hour plasma glucose measurements, showed
high sensitivity and accuracy, with moderate specificity for diagnosis of GDM. Its potential use as an alternative to standard
100-g OGTT should be evaluated in the prospective study.
Keywords : Oral glucose tolerance test (OGTT), Gestational diabetes mellitus (GDM), National diabetes data group (NDDG)
