The Effectiveness of Clinical Practice Guideline for Nasopharyngeal and Oropharyngeal Cancer to Reduce Acute Treatment Toxicity from Concurrent Chemoradiation
Nan Suntornpong MD*, Mathurot Sukkasem BNS*, Chiraporn Uwattanasombat BSc*, Nataya Samasanti MSc*, Kullathorn Thephamongkol MD*
Affiliation : * Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Objective : To evaluate the effectiveness of clinical practice guidline(CPG) for nasopharyngeal carcinoma (NPC) and
oropharyngeal carcinoma (OPC) on reducing acute toxicity during concurrent chemoradiation (CRT).
Material and Method: The prospective study enrolled 74 patients diagnosed of NPC and OPC that underwent concurrent
CRT.The feasibility of CPG was evaluated.
Results : Each checkpoint in CPG is feasible with 76% compliance of three in four points and 24% complete all points. Overall
grade 3 or 4 skin reaction and mucositis are 9 and 8% respectively.
Conclusion : CPG that consisted of preventive methods to reduce acute skin and oral mucosa toxicities in NP and OP patients
is easy to follow with 24 to 100% compliance. This can be feasible with consideration about immobilization device and energy
treatment machine.
Keywords : Nasopharyngeal cancer, Oropharyngeal cancer, Concurrent chemoradiation
