In Vivo Whole Body Dosimetry Measurement Technique of Total Body Irradiation: A 12-Year Retrospective Study Result from One Institute in Thailand
Thiti Swangsilpa MD*, Puangtong Kraiphibul MD**, Puangpen Tangboonduangjit PhD*, Chirapha Tannanonta MSc***, Tasanee Layangkul MSc*, Orawan Rattanasuwan BSc, RN*
Affiliation : * Radiation Oncology Division, Department of Radiology Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok,Thailand ** Maha Vajiralongkorn Cancer Center, Pathumthani, Thailand *** Chulabhorn Hospital, Bangkok, Thailand
Objective : The main problem of total body irradiation (TBI) is how to maintain radiation dose homogeneity throughout the
body during a treatment course. The simple set up treatment with non-complicated in vivo dosimetry measurement technique
is the ideal method to solve this problem. For this reason, the authors have reported the results of in vivo dosimetry
measurement method to prove the reliability of dose distribution from the authors’ TBI technique.
Material and Method: The authors reviewed the data of dose measurement record from 53 patients’ treatment files to report
the uniformity of absorbed in vivo dose distribution throughout the whole body from TBI with semiconductor detectors and
ionization chamber with the accepted homogeneity within + 10% of the prescribed dose. The result was reported in the term
of mean and standard deviation of absorbed dose difference from the prescribed dose.
Results : The uniformity of radiation dose distribution throughout the whole body of all patients calculated from semiconductors
was accepted with mean difference value of -3.2 + 2.5% from the prescribed dose and the difference of mean absorbed dose
value at midline point between semiconductor and ionization chamber was 4 + 3.3%.
Conclusion : This TBI dosimetry measurement technique has been proved to exhibit the reliability of dose homogeneity
throughout the whole body within the accepted value. This could be applied for use at any institute that has some limitation in
resources and small treatment room.
Keywords : Total body irradiation, Dsimetry measurement, Bone marrow transplantation
