Clinical Profiles of Thai Patients with Ocular Myasthenia Gravis in Siriraj Hospital
Supinda Leeamornsiri MD*,**, Niphon Chirapapaisan MD**, Wanicha Chuenkongkaew MD**
Affiliation : * Department of Ophthalmology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand ** Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Ninety-six patients with ocular myasthenia gravis (OMG) seen at Siriraj Hospital during 1994 to 2004 were retrospectively reviewed. There were 59 female (61.5%) and 37 (38.5%) male patients with mean ages of 39.5 and 33.8 years, respectively. Patients presented with initial symptoms of only ptosis in 46.9%, only diplopia in 13.5% and both ptosis and diplopia in 39.6%. However, diplopia alone is uncommon in childhood OMG. Fifteen percent developed systemic symptoms within two years of diagnosis. Thyroid function test was abnormal in 27.5% of investigated patients. Most abnormalities were hyperthyroidism. Thymoma associated with OMG is a rare condition. Most purely OMG patients can control the disease by pyridostigmine, prednisolone or immunosuppressive drugs.
Keywords : Ocular myasthenia gravis, Ptosis, Diplopia, Pyridostigmine, Generalized myasthenia gravis
