Abacavir Hypersensitivity Reaction: The First Case Report in Thailand and Literature Review
Chutinart Chinudomporn MD¹, Ornicha Thititagul MD¹, Woraphot Tantisiriwat MD, MPH²
Affiliation : ¹ Department of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand ² Department of Preventive Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand
Abacavir-related hypersensitivity reaction (ABC-HSR) is a life-threatening condition. The incidence is low since it could have been prevented
by screening with blood test for HLA-B*5701, which is strongly associated with this reaction. However, the affordability for the HLA-B*5701
screening test is still a challenging issue in many developing countries. Thai National Health Security Office (NHSO) recommends either using
HLA-B*5701 as a screening test or monitoring clinical presentation for ABC-HSR after using it. Therefore, the clinical presentation of ABC-HSR
should be acknowledged for the diagnosis of this condition and death prevention. This was the first reported case and literature reviewed of
ABC-HSR associated with the presence of the HLA-B*5701 allele in Thailand.
Received 16 June 2020 | Revised 20 August 2020 | Accepted 21 August 2020
doi.org/10.35755/jmedassocthai.2021.01.11569
Keywords : Abacavir, Hypersensitivity reaction, HLA-B*5701, Clinical presentation, Thailand
