Clinicopathological Characteristics of Mucinous and Non-Mucinous Adenocarcinoma in the Colon and Rectum in Rajavithi Hospital, Thailand
Paiboon Jivapaisarnpong MD*, Kanya Boonthongtho MSc**
Affiliation : * Department of Surgery, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand ** Division of Research and Technology Assessment, Department of Academic Affiliations, Rajavithi Hospital, Bangkok, Thailand
Background : The clinicopathological characteristics of colorectal mucinous adenocarcinoma (MA) are still controversial.
Most of the reports suggested that MA were associated with worse clinicopathological behavior and poorer prognosis than
non-mucinous adenocarcinoma (NMA) while the others showed no difference.
Objective : To compare clinicopathological characteristics and tumor recurrence of MA patients with those in NMA patients.
Material and Method: During the period of 2000 to 2009 in Rajavithi Hospital, a total of 427 colorectal adenocarcinoma
patient records consisting of 407 NMA and 20 MA were included in this study. Mean age, tumor location, TNM staging at
diagnosis, T- stage, N-stage, preoperative CEA level and recurrent rate of MA patients were compared with those of NMA
patients.
Results : The distribution of MA patients for gender, mean age, tumor location, TNM stage and preoperative CEA level were
similar to those of NMA patients (all p > 0.05). Only the tumor recurrence in MA was significantly more common than that
in NMA (p = 0.020, OR = 3.28 (1.14-9.43)), whereas the TNM stage was not significantly different from NMA (p = 0.530).
The metastatic site and pattern of metastasis also showed no statistical significance (p = 0.125).
Conclusion : The prognosis of MA is poorer than NMA. This may be associated with mucinous histological type itself.
Keywords : Colorectal mucinous adenocarcinoma, Mucinous carcinoma of colorectum, Colorectal mucinous carcinoma, Colorectal carcinoma.
