24-Hour Intraocular Pressure Control between Travoprost/Timolol Fixed Combination, Latanoprost/ Timolol Fixed Combination and Standard Timolol in Primary Open Angle Glaucoma and Ocular Hypertension
Pongsak Pachimkul MD*, Kanokwan Yuttitham MD*, Peerapong Thoophom MD*
Affiliation : * Department of Ophthalmology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand
Objectives: To evaluate the efficacy between Travoprost 0.004%/Timolol 0.5% fixed combination, Latanoprost 0.005%/
Timolol 0.5% fixed combination once a day in the morning and Timolol 0.5% twice a day in a 24-hour intraocular pressure
control (IOP).
Material and Method: The patients with primary open angle glaucoma and ocular hypertension was subjected. After 2-4
weeks of washout period, patients with daytime IOP > 21 mmHg and < 36 mmHg were admitted to the hospital for 24-hour
IOP monitoring every 3-hour interval starting from 9 am to 9 am the next day. The patients were randomly received
Travoprost-Timolol fixed combination, Latanoprost-Timolol fixed combination once a day or Timolol twice a day in the
studied eyes. Another 24-hour IOP monitoring was taken again 2 weeks later.
Results : 59 eyes from 32 patients were subjected. The mean initial IOP at 9 am was 21.6 mmHg. The mean reduction of IOP
ranging from 1.6 to 7.3 mmHg for Travoprost-Timolol group, 1.5 to 8.2 mmHg for Latanoprost-Timolol group and 2.2 to 5.6
mmHg for Timolol group. All three groups produced statistically significant reduction (p < 0.05) in mean IOP at all test times
except; at 3 am for the Travoprost-Timolol group; at 3 am, 12 midnight and 6 pm in the Latanoprost-Timolol group; and at
3 am and 9 pm in the Timolol group. The effects of IOP reduction of the combination drugs were greatest between 9 am and
3 pm with the morning dose of both combinations. There was no statistically significant difference in mean IOP reduction at
any test time between the 2 combination drug groups but they were both better than Timolol alone at 9 am and 3 pm.
Conclusion : A fixed combination of Travoprost 0.004% and Timolol 0.5% is as effective as a fixed combination of Latanoprost
0.005% and Timolol 0.5% and are better than Timolol 0.5% in 24-hour IOP control.
Keywords : 24 hour intraocular pressure, Fixed combination antiglaucoma drug
