Predictive Factor of Severe Renal Involvement in Children with Henoch-Schoenlein Purpura
Wanida Limpongsanurak MD*, Chookiet Kietkajornkul MD**, Srisupalak Singalavanija MD*
Affiliation : * Dermatology Unit, Department of Pediatrics, Queen Sirikit National Institute of Child Health, College of Medicine, Rangsit University, Bangkok, Thailand ** Nephrology Unit, Department of Pediatrics, Queen Sirikit National Institute of Child Health, College of Medicine, Rangsit University, Bangkok, Thailand
Objective : To find out which of the clinical manifestations or laboratory findings is the predictive factor of severe renal
involvement in children with Henoch-Schoenlein purpura (HSP).
Material and Method: Data of clinical manifestations and laboratory findings in children with HSP at Queen Sirikit National
Institute of Child Health between January 2003-December2007 were prospectively collected and analyzed.
Results : There were 168 cases, 86 boys and 82 girls (M:F ratio= 1.05:1), the age ranged from 2 to 15 years (mean + SD =
6.9 + 2.6 years, mode = 6.8 years). Development of severe renal involvement was identified in 11 cases (6.6 %). Abnormal
urinalysis (microscopic hematuria or proteinuria) on the day of diagnosis was statistically significant (p < 0.001) as a
predictive factor of severe renal involvement during follow-up. Early systemic corticosteroid administration due to severe
abdominal pain was not statistically significantly different between the patients with or without severe renal involvement.
Conclusion : Abnormal urinalysis on the day of diagnosis was the only predictive factor of severe renal involvement in
children with Henoch-Schoenlein purpura. Early systemic corticosteroid administration due to severe abdominal pain did not
prevent severe renal involvement.
Keywords : Henoch-Schoenlein purpura, Severe renal involvement
