Prevalence and Factors Associated with Microalbuminuria and Abnormal Renal Function in Thai Obese Adults
Supawadee Eiamthanasinchai MD*, Nopparat Laowahutanont MD**, Preyanuj Yamwong MD*, Tanyarat Teerapornlertratt MD**
Affiliation : * Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand ** Division of Nephrology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Objective : To determine the prevalence and factors associated with microalbuminuria and abnormal renal function in Thai
obese adults.
Material and Method: A cross-sectional study data was collected from 86 patients during October 2010 to February 2011 at
the obesity clinic and outpatient department of Siriraj Hospital. Obese patients with body mass index > 25 kg/m2 participated
in the present study. Exclusion criteria were the patients who refused participation or patients with end stage renal disease who
were under treatment with hemodialysis or continuous ambulatory peritoneal dialysis. A questionnaire was used for collecting
information on demographic data, e.g., age, sex, residence, educational level, underlying diseases and drugs use, family
history of obesity, family history of renal disease, smoking, or alcohol drinking; height, weight, body mass index, waist
circumference, blood pressure, blood chemistry test and urine analysis were collected. The abnormal function of the kidney
was assessed by presence of microalbuminuria or estimated glomerular filtration rate below 90 mL/min/1.73 m2.
Results : The prevalence of microalbuminuria in obese patients was 28% and prevalence of chronic kidney disease stage 2 or
more was 22%. Factors associated with microalbuminuria were FBS > 126 mg/dL (OR = 6.2, 95% CI: 1.7-22.1), hyperu-
ricemia (serum uric acid > 7 mg/dL)(OR = 3.2, 95% CI: 1.0-9.8). Factors associated with chronic kidney disease stage 2 or
more were age > 55 years (OR = 7.8, 95% CI: 2.5-24.1), Angiotensin II receptor blocker (ARB) use (OR = 4.1, 95% CI: 1.3-
12.3) and hyperuricemia (serum uric acid > 7 mg/dL)(OR = 4.5, 95% CI: 1.5-13.5).
Conclusion : Early identification of obesity and metabolic syndrome and modifying pattern of life style behavior in obese
adults carrying risk factors might be beneficial in preventing and delaying the progression of chronic kidney disease in
Thailand.
Keywords : Obesity, Microalbuminuria, Chronic kidney disease
