Prevalence and Type of Associated Syndromes in Patients with Cleft Lip and Cleft Palate Who Received the Treatment in Tawanchai Center until 4-5 Years of Age
Khunton Wichajarn MD*, Ouyporn Panamonta MD*, Suteera Pradubwong MSN**, Manat Panamonta MD*, Wiboon Weraarchakul MD*, Bowornsilp Chowchuen MD***
Affiliation : * Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand ** Division of Nursing, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand *** Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Background : Understanding the genetic etiologies of cleft lip and palate (CLP) is important for improved prevention,
treatment, and prognosis for patients affected by CLP.
Objective : To report the prevalence and the type of associated syndromes in Northeastern Thai patients with CLP.
Material and Method: A retrospective study of 123 cleft lip/palate children aged 4-5 years was carried out at the Tawanchai
Cleft Center, Khon Kaen University during the period from October to December 2011. Data were collected by reviewing the
patient’s medical records.
Results : Seventeen (14%) of the 123 children had multiple malformations and five (4%) of these children had associated
syndromes. Syndromes were identified in 5 (29%) of the 17 children who had associated malformations. The syndromes were
Apert, Cleft lip/palate-ectodermal dysplasia, Kabuki, Oculo-Auriculo-Vertebral Spectrum, and Velocardiofacial syndrome.
Conclusion : Recognition of the associated syndrome in a patient with CLP is essential to assess the problem of the patient,
provide necessary treatment and the appropriate methodology of prevention.
Keywords : Children, Cleft lip, Cleft palate, Syndrome
