Xanthones from Mangosteen (Garcinia mangostana): Multi-targeting Pharmacological Properties
Sarawut Jindarat MD, PhD*
Affiliation : * Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok, Thailand
Objective : This review focuses on mangosteen pericarp extracts, xanthones and derivatives for the future laboratory experiment
and development in pharmacological aspects.
Material and Method: All relevant literature databases were searched up to 2 March 2014. The search terms included
mangosteen, xanthone, mangostin, and gatanin in all of the human, animal, in vitro and in vivo studies. Anti-inflammation,
antioxidant, antibacterial, anticancer and antiulcer properties of each substance were the key parameters.
Results : Xanthones are a group of oxygen-containing heterocyclic compounds including alpha-mangostin, gamma-mangostin,
mangosteen extract, xanthone derivatives and synthetic xanthones, which provide remarkable and diverse pharmacological
effects such as anticancer, antioxidant, anti-inflammatory and antimicrobial activities.
Conclusion : These xanthone compounds may play a major role in therapeutic treatment of the diseases but precise mechanisms
of action are still unclear and need further investigation.
Keywords : Mangosteen, Xanthones, Mangostin, Anti-inflammation, Antioxidant, Antibacterial, Anti-cancer
