Outcome of Acute Lymphoblastic Leukemia Treatment Using National Protocols at the Queen Sirikit National Institute of Child Health
Somjai Kanjanapongkul MD*
Affiliation : * Hemato/Oncology Unit, Queen Sirikit National Institute of Child Health, College of Medicine, Rangsit University, Bangkok, Thailand
Objective : To evaluate the outcome of acute lymphoblastic leukemia (ALL) treatment at the Queen Sirikit National Institute of
Child Health (QSNICH) after using national protocols.
Material and Method: Seventy-six pediatric patients with newly diagnosed with ALL, who were treated in Queen Sirikit
National Institute of Child Health using the national protocols during March 2006 and February 2008, were enrolled. The
national protocols were sub-classified by clinical risk factors and morphology of leukemic cells of the patients at initial
presentation into 3 groups as standard risk (ALL-01-05), high-risk (ALL-02-05), and mature B-ALL or L3 (NHL-04-06)
protocol. Overall survival (OS) and event-free survival (EFS) were determined by using Kaplan-Meier survival curves.
Results : The overall survival rate of ALL patients treated using the national protocols was 83.85% (88.06% in standard
group, 82.01% in high-risk group, and 75% in L3 protocol). The mortality rate and event-free survival of ALL patients was
13.33% and 72.50%, respectively.
Conclusion : The national protocols for ALL showed benefit in the improvement of outcomes from treatment in childhood
ALL.
Keywords : Childhood ALL, National protocols, Outcome
