Demographics, Clinical Features, Outcome and Prognostic Factors of Guillain-Barre Syndrome in Thai Children
Somjit Sri-udomkajorn MD*, Sirorat Suwannachote MD*
Affiliation : * Division of Child Neurology, Department of Pediatrics, Queen Sirikit National Institute of Child Health, College of Medicine, Rangsit University, Bangkok, Thailand
Objective : To describe demographics, clinical profiles, management, outcomes and to determine factors associated with
severity in Guillain-Barre Syndrome (GBS).
Material and Method: Medical records of GBS patients in Queen Sirikit National Institute of Child Health during 2000-2009
were searched. The data included demographics, clinical features, management and outcomes after 6 months to determine
prognostic factors.
Results : Forty-eight patients with GBS were studies. Mean age of onset was 5 years. Male and female ratio was 1.4:1. History
of antecedent infection was 73 %. Clinical presentations included limb weakness 100%, respiratory distress 27%, facial palsy
27%, autonomic nervous dysfunction 22% and ataxia 17%. Nerve conduction study revealed demyelinating process in 57%,
axonopathy in 26% and mixed type in 17%. Clinical outcomes were satisfactory in most of the patients except three patients
who still had disability eighteen months after onset. Autonomic nervous dysfunction was a significant factor to determine the
severity.
Conclusion : The demographic and clinical features of GBS were similar to other published studies. The autonomic nervous
dysfunction was a significant predictor for adverse clinical course. All but three patients had complete, full recovery.
Keywords : GBS, Prognostic factors, Outcome
