Echocardiographic and Clinical Characteristics Cross-Sectional Study in Association with Thai Peritoneal Dialysis Patients: Data from a Single Center Study
Teeranan Angkananard MD*, Siribha Changsirikulchai MD*, Jirayut Janma MD*, Thanapath Wannasiri BSc*, Piyathida Sangthong BSc*
Affiliation : * Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand
Background : The dialysis patients have a lot of changes in cardiac structure and function detected by echocardiography and
they have been recognized as key outcome predictors. However, the available data regarding echocardiographic alterations
in Thai Continuous Ambulatory Peritoneal Dialysis (CAPD) patients is limited. This study aimed to determine the correlation
between baseline clinical and echocardiographic characteristics of Thai CAPD patients.
Material and Method: This study was a single center and cross-sectional observational study, which enrolled all CAPD
outpatients (104 patients), treated at Srinakharinwirot Medical University between 1 September 2012 and 31June, 2014.
Their demographic and echocardiographic data were collected one time and the latest laboratory data to the patient’s
echocardiographic study date were analyzed.
Results : One hundred and four patients (50 men and 54 women) whose mean age was 59.4+12.7 years and median duration
of CAPD was 12 months were recruited. An extremely high prevalence of elevated left ventricularmass index (LVMI), 82.7%
was found which mean LVMI was higher in male than female (166.2+55.6 vs. 131+47.6 g/m2). All patients had diastolic
dysfunction and most of them had diastolic dysfunction grade I. The study factors of male gender, history of hypertension, high
serum phosphate, low hemoglobin level, corrected QT interval, and duration of CAPD longer than 24 months can predict the
variation of LVMI. Interestingly, the study found that a duration of CAPD of longer than 42 months might reduce right
ventricular systolic pressure.
Conclusion : This study revealed a higher prevalence of left ventricular hypertrophy (LVH) in Thai CAPD patients when
compared with previous studies and anemia still be an important independent factor for developing LVH. Longer period of
CAPD may regress LVH and lower RVSP that should be proven by longer well-designed prospective studies.
Keywords : Peritoneal dialysis, Echocardiography, Left ventricular hypertrophy, Pulmonary hypertension, End-stage renal disease (ESRD), Continuous ambulatory peritoneal dialysis (CAPD), Thai
