Risk Factors for Post Endoscopic Retrograde Cholangiopancreatography Cholangitis
Thana Boonsinsukh MD*, Vichit Viriyaroj MD*, Hariruk Yodying MD*
Affiliation : * Department of Surgery, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand
Background : Cholangitis is the one of complications in post endoscopic retrograde cholangiopancreatography (post-
ERCP). Few studies investigated risk factors for post-ERCP cholangitis and the results showed different outcomes.
Objective : The aim of the study was to determine the contributing risk factors for post-ERCP cholangitis.
Material and Method: The medical records of patients who underwent ERCP from January 2013 to December 2015 were
retrospectively reviewed. We excluded patients who had cholangitis before ERCP. All patients received intravenous prophylaxis
antibiotic before the procedure. Demographic data, interested factors and result were collected. Univariate and multivariate
analysis were used to identify risk factor for post-ERCP cholangitis.
Results : 227 patients enrolled where 204 (89.9%) of them were receiving therapeutic procedure. 156 (68.7%) patients were
performed by high experience endoscopists (performing >50 ERCPs per year). The success rate was 87.7%. Post-ERCP
cholangitis occurred in 20 (8.8%) patients as a result of therapeutic procedures. By univariate analysis, 8 variables were
identified. They were male sex, age >60 year, no epigastric pain, albumin <2.5 gm/dL, bile duct cancer, common bile duct
stones, change and remove bile duct stent. Multivariate analysis showed that age >60 year, albumin <2.5 gm/dL and remove
bile duct stent were significantly associated with post-ERCP cholangitis.
Conclusion : Age >60 year, albumin <2.5 gm/dL and remove bile duct stent are three major risk factors for post-ERCP
cholangitis.
Keywords : Risk factor, Post-ERCP cholangitis, Endoscopic retrograde cholangiopancreatography
