Pazopanib-Induced Reversible Left Ventricular Systolic Dysfunction

Worawut Roongsangmanoon¹, Kantarat Wattanawinitchai¹, Chanchai Charonpongsuntorn¹, Piyanant Chonmaitree¹, Arthit Wongsoasup¹, Nattapun Rattanajaruskul¹, Teeranan Angkananard¹

Affiliation : ¹ Department of Internal Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand

Pazopanib is a tyrosine kinase inhibitor used for the treatment of advanced renal cell carcinoma and advanced soft tissue sarcoma. The authors describe a patient with advanced renal cell carcinoma who developed severe hypertension and severe left ventricular systolic dysfunction after starting pazopanib therapy with subsequent recovery of left ventricular ejection fraction upon treatment interruption.

doi.org/10.35755/jmedassocthai.2022.S01.00030

Keywords : Pazopanib, Cardiotoxicity, Heart failure

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