The Efficacy of Combined Low Dose of Allopurinol and Benzbromarone Compared to Standard Dose of Allopurinol in Hyperuricemia
Somchai Akkasilpa MD*, Manathip Osiri MD*, Utis Deesomchok MD*, Yingyos Avihingsanon MD*
Affiliation : * Department of Medicine, Faculty of Medicine, Chulalongkorn University
Objective : To compare the efficacy of combined low dose of hypouricemic drugs (Allopurinol 100 mg and
benzbromarone 20 mg; Allomaron(cid:31)) and standard dose 300 mg of allopurinol in hyperuricemia.
Materials and Methods : A prospective, open study of 94 hyperuricemic patients was done at King
Chulalongkorn Memorial Hospital. Each group of 47 patients was given a combined low dose of hypouricemic
drugs (Allopurinol 100 mg and benzbromarone 20 mg; Allomaron(cid:31)) and a standard dose 300 mg of
allopurinol. Serum uric acid was measured before and 4 weeks after receiving the drugs. The efficacy was
measured from the difference of the level of serum uric acid before and after receiving the drugs.
Results : The patients receiving the combined low dose of hypouricemic drugs and standard dose of allopurinol
showed a mean reduction of serum uric acid of 2.5 + 3.4 mg/dl and 4.1 + 2.7 mg/dl consecutively. There was
a statistically significant difference between the 2 groups (P = 0.010).
Conclusion : This study demonstrates that the efficacy of standard dose 300 mg of allopurinol is superior to
a combined low dose of allopurinol and benzbromarone in lowering the level of serum uric acid level.
Keywords : Allopurinol, Benzbromarone, Allomaron, Hyperuricemia
