Squamous Cell Carcinoma Arising in Chronic Ulcers in Leprosy
Kowit Kampirapap, MD*, Tara Poonpracha, MD**
Affiliation : * Raj-Pracha Samasai Institute, Department of Disease Control, Ministry of Public Health, ** Army Institute of Pathology, Phramongkutklao Medical College
Squamous cell carcinoma (SCC) arising in chronic ulcers of leprosy patients is uncommon. A
retrospective analytical study of 416 biopsy specimens of chronic ulcers during 1976-2000 occuring on the
extremity of leprosy patients was performed. Pathologic examination showed that 217 specimens (52.2%)
were reported as pseudoepitheliomatous hyperplasia (PH). A total of 102 (24.5%) specimens reported as
SCC, involving 100 individual patients (69 males, 31 females). SCC was localized on the lower extremity in
87 specimens (85.3%). No significant difference was observed between left and right foot using Chi-square
test. The sole was the commonest site of involvement, and then the heel. SCC on the upper extremity which
was much less common, presented in 15 specimens (14.7%). The tumor was localized on the palm in 10
specimens (right: 9, left: 1).
SCC in chronic ulcers of leprosy patients were much more common on the lower extremity than on
the upper extremity. Most of the tumors on the upper extremity were localized on the right palm. This
emphasizes the need for an active policy of prevention of disability in leprosy control programs.
Keywords : Squamous cell carcinoma, Chronic ulcers, Leprosy
