Does Preloading with Colloids Prevent Hemodynamic Changes when Neurosurgical Patients are Subsequently Changed to the Seated Position?(cid:31)
Phuping Akavipat, MD, FRCAT*, Paungpaga Metta, BSc (nursing)*
Affiliation : (cid:31) Funding from the Ministry of Public Health * Department of Anesthesiology, Prasat Neurological Institute
Objective : This prospective, randomized, double-blind study was designed to determine and compare the
usefulness of preloading colloids (Haemaccel(cid:31)) 10 ml/Kg before positioning whether it can prevent
hemodynamic changes during seated positioning or not.
Materials and Methods : The authors studied 20 patients by randomly dividing them into 2 groups. The control
group was given crystalloid as maintenance and deposit replacement but the study group was given extra
colloids 10 ml/Kg 30 minutes before starting general anesthesia. Both groups were monitored and given
anesthesia, balanced technique. Systolic and diastolic blood pressures, heart rate, central venous pressure
(CVP) at different time intervals in the sitting position for 30 minutes were recorded. Statistical analysis was
done by Student t-test, Chi-square test and ANOVA (p-value < 0.05 considered significant).
Results : The results showed that systolic blood pressure at 15, 20, 30 minutes and CVP at 15, 25, 30 minutes
after positioning in the study group was maintained significantly compared to the control group and there
were no significant changes in diastolic blood pressure and heart rate. There were no other complications
during the sitting period.
Conclusion : It is concluded that preloading colloid fluid prior to repositioning could prevent the decrease
of systolic blood pressure and central venous pressure during sitting positioning without other complications.
Keywords : Sitting position, Systolic blood pressure, Diastolic blood pressure, Heart rate, Central venous pressure
