The Correlation of Insulin Resistance and Renal Function in Non Diabetic Chronic Kidney Disease Patients 1
Bancha Satirapoj MD*, Ouppatham Supasyndh MD*, Apussanee Boonyavarakul MD**, Lersan Luesutthiviboon MD*, Panbubpa Choovichian MD*
Affiliation : * Division of Nephrology, **Division of Endocrinology, Department of Medicine, Phramongkutklao Hospital
1Poster presentation at Annual Dialysis Conference 2005, University of Missouri School of Medicine,
Columbia, Missouri, February 28-March 2, 2005, Tampa, Florida, USA
Introduction: A greater degree of insulin resistance may predispose to renal injury by worsening renal
hemodynamics through the elevation of glomerular filtration fraction. However, there are sparse data on the
relationship between insulin resistance, glomerular filtration rate (GFR) and body composition in chronic
kidney disease (CKD) without diabetes.
Objectives : To evaluate the relationship between insulin resistance, total body fat and GFR in CKD without
diabetes.
Materials and Methods : The authors screened 84 non-diabetic CKD patients according to the K/DOQI
definitions and only 78 patients were enrolled into the study (CKD stages 2-4, GFR between 15 and 90 ml/min/
1.73 m2). Insulin resistance was evaluated by homeostasis model assessment (HOMA-IR). Bioelectrical
impedance analysis was performed to determine the percentage of total body fat. GFR was calculated by
the average of creatinine and urea clearances.
Results : The correlation analysis showed that HOMA-IR was positively correlated with percent body fat
(r = 0.32, P<0.05), BMI (r = 0.46, P<0.01), serum triglyceride (TG) (r =0.29, P<0.01), and mean arterial
pressure (r =0.25, P<0.05), but not significantly correlated with GFR, age, cholesterol, HDL, uric acid
and 24-hr urinary protein.
Conclusion : In non-diabetic CKD patients, the independent factor for insulin resistance was the amount of
total body fat. The insulin level and HOMA-IR were not dependent on the GFR in the present study.
Keywords : Insulin resistance, Body fat, Chronic kidney disease
