Cutaneous Anaplastic Large Cell Lymphomas: A Report of 9 Cases from Thailand
Sasima Eimpunth MD*, Panitta Sittinamsuwan MD**, Penvadee Pattanaprichakul MD*, Narumol Silpa-archa MD*, Piyaroj Sethabutra MD*, Leena Chularojanamontri MD*, Suchanan Hanamornroongruang MD**, Punkae Mahaisavariya MD*
Affiliation : * Department of Dermatology, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand ** Department of Pathology, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand
Background : Anaplastic large cell lymphoma (ALCL) is one type of lymphoma, which is characterized by the proliferation of
pleomorphic large atypical lymphoid cells expressing CD30 antigen. ALCL involving skin can be either primary cutaneous
disease or cutaneous involvement secondary from systemic disease. Data of clinical manifestation of cutaneous ALCL in Thai
patients is limited. ALCL in Thai patients may differ from other groups of patients.
Objective : To study the clinical manifestation of cutaneous ALCL in patients of Faculty of Medicine Siriraj Hospital, Thailand
Material and Method: Medical records of nine patients with histopathologic diagnosis of ALCL from skin biopsy at Faculty
of Medicine Siriraj Hospital were reviewed.
Results : Of nine patients, four patients were diagnosed as primary cutaneous ALCL, four patients as systemic ALCL with
secondary skin involvement, and one patient as combined primary cutaneous ALCL and lymphomatoid papulosis. Three
primary cutaneous ALCL patients had no recurrence of disease during 6-year follow-up. However, all systemic ALCL
patients died at one day to 1.5 years after diagnosis.
Conclusion : Clinical manifestation and clinical course of Thai patients with anaplastic large cell lymphoma corresponded
with the data from other patient population.
Keywords : Lymphoma, Skin, CD30, Lymphoproliferative disorder
