Outcome of Recurrent and Persistent Disease of Malignant Ovarian Germ Cell Tumor: A Retrospective Analysis at King Chulalongkorn Memorial Hospital
Ruangsak Lertkhachonsuk MD*, Tarinee Manchana MD*, Wichai Termrungruanglert MD*, Apichai Vasuratna MD*, Tul Sittisomwong MD*, Pongkasem Worasethsin MD*, Nakarin Sirisabya MD*, Nipon Khemapech MD*, Damrong Tresukosol MD*
Affiliation : * Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University
Malignant ovarian germ cell tumor has one of the most successful treatment outcomes in gynecologi- cal malignancy. More than 80% of the patients can be cured from this rare type of tumor. However, patients with recurrent and persistent disease after primary treatment are still the problem of management. The present study has reviewed the treatment outcome of this cancer in King Chulalongkorn Memorial Hospital during the 12 years period from 1993 to 2004. The overall cases of malignant ovarian germ cell tumor were 71 cases, 8 cases had recurrent disease after primary treatment and all cases received platinum-based chemotherapy for the salvage treatment. All patients in this group received long-term survival with median survival time of 87 months. In patients with persistent disease, 10 cases that resisted to first line adjuvant chemotherapy. Cisplatin and Etoposide regimen was applied as second line treatment, but none of these patients received long term response. The survival outcomes in these 2 groups are significantly different. The overall survival from the treatment of malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital was 85.1%. In conclusion, the outcome of treatment in patients with recurrent disease after non-platinum chemotherapy is excellent. Salvage therapy in this group should contain platinum-based regimen. Patients whose disease persisted after platinum-containing regimen had a poor survival outcome.
Keywords : Malignant ovarian germ cell tumor, Recurrent disease, Persistent disease
