The Outcomes and Prognostic Factors of Patients with Soft-Tissue Sarcoma
Piya Kiatisevi MD*, Apichat Asavamongkolkul MD**, Rapin Phimolsarnti MD**, Saranatra Waikakul MD**, Suchart Benjarassamerote MD***
Affiliation : * Institute of Orthopaedic, Lerdsin General Hospital ** Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University *** Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University
The present study evaluates the outcomes and prognostic factors in patients with soft-tissue sarcomas of the extremities, trunk, head and neck region. A retrospective study of 104 patients who underwent treatment was conducted on 48 males and 56 females with a mean age of 44.5 years (range, 10-85 years). Seventy-eight patients had high-grade sarcomas and most tumors (89.5 percent) were located at the extremities. One hundred patients were treated by surgery and 51 patients were treated by both surgery and radiation therapy. With the median follow-up time of 24.5 months, local recurrence developed in 26 patients (25 percent) and distant metastasis developed in 29 patients (27.9 percent). The actuarial overall 3-year disease-specific survival rate were 74.2 percent. Multivariate statistical analysis revealed that positive surgical margin and occurrence of distant metastasis were significant predictors for overall survival. Positive surgical margin was the only factor that increased the risk of local recurrence and older age (> 60 years) was only the factor that increased the risk of distant metastasis. The results reaffirm the importance of the surgical margin where uncontrolled local disease affects the risk of local failure and disease-specific survival. Occurrence of distant metastasis is associated with older age (> 60 years) and decreases disease-specific survival of the patients.
Keywords : Soft-tissue sarcoma, Outcomes, Prognostic factors
