Malignant Peripheral Nerve Sheath Tumor of Breast in Patient without Von Recklinghausen’s Neurofibromatosis: A Case Report
Chaiyut Thanapaisal MD*, Supinda Koonmee MD**, Sarithorn Siritunyaporn MD**
Affiliation : * Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen ** Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen
Malignant peripheral nerve sheath tumor (MPNST) of the breast without Von Recklinghausen’s neurofibromatosis (VRN) is extremely rare. The authors report a 19 year-old woman who presented with a 12 month history of a painless mass of the left breast. Tissue biopsy was performed. The histologic diagnosis was made with immunohistochemical study in which the tumor showed positivity of vimentin, S-100 protein, neuron-specific protein(NSE), neurofilament protein(NF) and glial fibrillary acidic protein(GFAP). The patient was referred for radiation therapy after simple mastectomy.
Keywords : Breast tumor, Malignant peripheral nerve sheath tumors, von Recklinghausen’s neurofibromatosis
