Reversible Posterior Leukoencephalopathy Caused by Azathioprine in Systemic Lupus Erythematosus
Chingching Foocharoen MD*, Somsak Tiamkao MD*, Jiraporn Srinakarin MD**, Nittaya Chamadol MD**, Kittisak Sawanyawisuth MD*
Affiliation : * Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen ** Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen
The authors report a case of systemic lupus erythematosus with posterior leukoencephalopathy who presented with headache, tonic-clonic seizure, loss of consciousness and bilateral loss of vision, after taking azathioprine for three weeks. The patient had hypertension with normal eye grounds. The brain CT showed a hypodensity lesion at both bilateral occipital lobes, mainly in the white matter. The symptoms and follow-up MRI were improved after the control of hypertension and discontinuation of azathioprine.
Keywords : Systemic lupus erythematosus, Posterior leukoencephalopathy, Azathioprine, White matter lesion, Seizure, Immunosuppressive agent
