Future Cancer Management with Stem Cell Knowledge and Technology
Sorapop Kiatpongsan MD*,**, Apiwat Mutirangura MD, PhD***,****, Yuen Tannirandorn MD*
Affiliation : * Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University ** Chulalongkorn Gene and Stem Cell Therapy Research Program *** Department of Anatomy, Faculty of Medicine, Chulalongkorn University **** Molecular Biology and Genetics of Cancer Development Research Unit, Faculty of Medicine, Chulalongkorn University
Cancer has been proposed as a result of abnormal control of growth and development of stem cells for more than century. This is the “cancer stem cell hypothesis”. Both cancer and stem cells share many common especial properties. They are immortal and have good differentiation potential. In addition, organogenesis and carcinogenesis are very similar processes. Recently, more evidence and convincing data from stem cell biology research are supporting this concept. Furthermore, the research provides new promising approaches for cancer diagnosis and treatment based on stem cell knowledge and technology. Upcoming data and evidence may revolutionize cancer management, making it more effective and safer.
Keywords : Stem cell, Cancer, Carcinogenesis, Cancer stem cell hypothesis, Symmetric division, Asymmetric division
