Epstein-Barr Virus Associated Lymphoepithelial Carcinoma of the Parotid Gland; A Clinicopathological Report of Three Cases
Noppadol Larbcharoensub MD*, Nattha Tubtong Cert MLT*, Veeraphol Praneetvatakul MD**, Atcharaporn Pongtippan MD*, Juvady Leopairat MD*, Vorachai Sirikulchayanonta MD*
Affiliation : * Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University ** Department of Otolaryngology, Faculty of Medicine Ramathibodi Hospital, Mahidol University
Lymphoepithelial carcinoma is a relatively uncommon malignant tumor of the salivary gland demon- strating malignant epithelial cells with dense lymphoid stroma. The authors report three cases of lymphoepithelial carcinoma associated with Epstein-Barr virus of the right parotid gland with clinically presenting as painless, gradual enlargement of the preauricular mass. The histopathologic examination of the parotid gland is characterized by malignant epithelial cells with dense lymphoid stroma. Immunohistochemi- cal stains show positive reactivity to cytokeratin and p53 in malignant epithelial cells. In situ hybridization of the Epstein-Barr virus-encoded Ribonucleic acid shows positivity in malignant epithelial cells. Clinical and pathologic features with relevant literatures are discussed. These are the first reported cases of primary parotid lymphoepithelial carcinoma associated with Epstein-Barr virus infection in Thailand and Southeast Asia.
Keywords : Lymphoepithelial carcinoma, Undifferentiated carcinoma, Parotid gland, Epstein-Barr virus, In situ hybridization
