Efficacy of Cellulose Triacetate Dialyzer and Polysulfone Synthetic Hemofilter for Continuous Venovenous Hemofiltration in Acute Renal Failure
Warangkana Pichaiwong MD*, Asada Leelahavanichkul MD**, Somchai Eiam-ong MD**
Affiliation : * Department of Medicine, Sirindhorn Hospital ** Divison of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University Hospital
Objective : To compare the clearance performances and biocompatibility between the modified cellulose
membrane and the standard synthetic membrane in continuous renal replacement therapy (CRRT)
Materials and Methods : Seventeen patients with acute renal failure (ARF)were treated with separated
continuous veno venous hemofiltration (CVVH) system conducted with the pre-dilution mode. The modified
cellulose used was a Sureflux150E(cid:31) (cellulose triacetate) and the standard synthetic membranes used was an
AV-400. Blood and replacement flow rate were kept at 100 and 20 mL/min, respectively. Ultrafiltraion rate was
1,200 mL/hr. Samplings of blood and ultrafiltrate were collected at baseline, 2, 8, 16, and 24 hr.
Results : Patients in both methods could similarly tolerate CRRT with only minor complications. Sureflux
150E(cid:31) and AV-400(cid:31) provided comparable values of sieving coefficients and clearances of small solutes. The
albumin loss in ultrafiltrate by Sureflux 150E(cid:31) was greater than AV-400(cid:31). The values of life span and
biocompatability of both hemofilters were not different.
Conclusion : Because of the excellent efficacy and the much cheaper cost, the modified cellulose membrane
could be an appropriate alternative to standard synthetic membrane in CRRT.
Keywords : Continuous renal replacement therapy, Modified cellulose membrane, Standard synthetic membrane
