Update in Pathophysiology and Histopathology of Focal Segmental Glomerulosclerosis
Talerngsak Kanjanabuch MD*, Songkiat Lewsuwan MD*, Chagriya Kitiyakara MD**, Boonyarit Cheunsuchon MD***, Somchai Eiam-Ong MD*
Affiliation : *Department of Medicine, Faculty of Medicine, King Chulalongkorn University Hospital, **Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, ***Department of Pathology, Faculty of Medicine, Sririraj Hospital, Mahidol University, Bangkok, Thailand 10330
Focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome in an adult worldwide. The prevalence of FSGS is estimated as being 20-30% in adults over the age of 15 years and slightly higher (30-35%) in the elderly (age > 60 years). The diagnosis solely relies on pathologic findings, which sclerosis involves some, but not all glomeruli (focal), and sclerosis affects a portion, but not the entire, glomerular tuft (segmental). The pathogenesis remains inconclusive but podocyte injury has been postulated. Even though steroid is the mainstay treatment, only 20-40% of patients are complete respond.
Keywords : FSGS, Pathology, Glomerulosclerosis, Pathophysiology
