A Comparison of the Efficacy of Sublingual and Oral Misoprostol 400 Microgram in the Management of Early Pregnancy Failure: A Randomized Controlled Trial
Orada Patamasingh na ayudhaya MD*, Yongyoth Herabutya MD*, Boonsri Chanrachakul MD*, Nathpong Israngura Na Ayuthaya MD*, Pratak O-Prasertsawat MD*
Affiliation : * Department of Obstetrics and Gyneacology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Objective : To compare repeated doses of sublingual with oral misoprostol in the medical management of early
pregnancy failure.
Materials and Methods : One hundred and thirty eight women with a period of gestation less than 20 week
calculated by her last menstrual period and less than 12 weeks by size were sequentially allocated to two
groups to receive either 400 µg of misoprostol orally or sublingually every 4 hours until termination of
pregnancy was completed.
Results : There is no difference in the mean induction to abortion interval. Fever and chill were more common
in sublingual group compared with oral group. The other adverse effects were similar and included nausea,
vomiting, diarrhea, abdominal pain, and headache.
Conclusion : Sublingual misoprostol is as effective as oral route. Most adverse effects are similar in both
groups except fever was more common in sublingual group.
Keywords : Misoprostol, Early pregnancy failure, Management, Sublingual, Oral
