Lipodystrophy and Dyslipidemia in Human Immunodeficiency Virus-Infected Thai Patients receiving Antiretroviral Therapy
Yaowaluk Chuapai MD*, Sasisopin Kiertiburanakul MD*, Kumthorn Malathum MD*, Somnuek Sungkanuparph MD*
Affiliation : * Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
Background : Lipodystrophy and dyslipidemia are increasing problems in HIV-infected patients receiving
antiretroviral therapy (ART).
Objective : Determine the prevalence and predicting factors for lipodystrophy and dyslipidemia in these
patients.
Materials and Methods : A cross-sectional study was performed on HIV-infected patients receiving ART in
January 2006. Clinical assessment for lipodystrophy and blood tests for lipid profile were obtained.
Results : There were 56 patients with a mean age of 42.3 years and 71.4% were male. Lipodystrophy was
detected in 66.1%. Baseline characteristics between patients with and without lipodystrophy were similar
except for age, history of receiving d4T and undetectable HIV-RNA (p < 0.05). There was a high prevalence of
dyslipidemia (53.6%). By logistic regression, undetectable HIV-RNA (odds ratio (OR) 6.4, p = 0.016) and
receiving d4T (OR 7.4, p = 0.022) are predicting factors for lipodystrophy.
Conclusion : Lipodystrophy and dyslipidemia in HIV-infected Thai patients receiving ART are common. Clini-
cal monitoring for these abnormalities during ART is highly recommended.
Keywords : Lipodystrophy, Dyslipidemia, HIV, Prevalence, Antiretroviral therapy
