Effectiveness of Recombinant Activated Factor VII (rFVII a) for Controlling Intractable Postpartum Bleeding: Report of Two Cases and Literature Review
Mayuree Jirapinyo MD*, Jittima Manonai MD*, Yongyoth Herabutya MD*, Suporn Chuncharunee MD**
Affiliation : * Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University ** Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Background : Recombinant activated factor VII is used for the treatment in patients with inherited or acquired
hemophilia with inhibitors and congenital factor VII deficiencies.
Objective : Using recombinant activated factor VII in primary postpartum hemorrhage.
Materials and Methods : Two cases of women who had postpartum hemorrhage and were treated with recombi-
nant activated factor VII after all conventional treatment failed.
Results : The intractable hemorrhage stopped after treatment with recombinant activated factor VII
Conclusion : The present report showed that massive postpartum hemorrhage that failed to all procedures was
controlled successfully by recombinant activated factor VII
Keywords : Intractable postpartum hemorrhage, Recombinant activated factor VII, rFVIIa
