Effectiveness of Activated Hydrogen Ions in Neutralizing Paraquat Intoxication in Rats(cid:31)
Sawang Saenghirunvattana MD*, Piboon Laohathai MD*, Sompol Sangguanrungsirikul MD**, Surapon Worapongpaiboon MD, FCAP*, Narumol Masakul MBA*, Kasem Saenghirunvattana***
Affiliation : (cid:31) Supported by Prasert Prasatthongosot Foundation * Samitivej Hospital, ** Chulalongkorn University Hospital, *** Siriraj Hospital
Objective : Investigate the effectiveness of H4O in preventing the paraquat’s effect in rats.
Materials and Methods : Disease-free male spraque Dawley rats were used in the experiment. They were divided
into two groups of 5, as the control group and the experiment group. All rats were poisoned with paraquat.
The control group was fed water (H2O) while the experiment group was fed activated hydrogen ions (H4O).
Results : The mortality of rats was equal (40%) in both groups. The control group died earlier than the
experimental group (48 hours, 96 hours). In the rats that could survive till 1 month, the pathology of the lungs
in the experimental group revealed less severity than the control group.
Conclusion : This may reflect the protective effects of activated hydrogen ions in the lungs, which are abundant
in oxygen, and may offer fruitful results in humans.
Keywords : Activated hydrogen ions, Paraquat, Interstitial hemorrhage
