Pathologically Different Features and Fibrosis Scores in Chronic Hepatitis C Genotypes 3 and 1 Ananya Manuyakorn MD*, Tawesak Tanwandee MD**, Kanit Atisook MD*
* Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University ** Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
Affiliation :
Background : Chronic hepatitis C genotypes 3 and 1 are the two most common genotypes in Thailand.
Objective : Identify the pathologically different features between genotypes 3 and 1and to compare the fibrosis
score of Knodell HAI and Ishak modified HAI.
Materials and Methods : The pathological features of 114 liver biopsies were evaluated.
Results : Steatosis was more commonly found in genotype 3 than in genotype 1 (97.1% vs. 77.8%, p = 0.001).
Portal lymphoid follicles were commonly found, but bile duct damage was uncommon. The majority of portal
tracts showed partial involvement. The majority of patients had Knodell fibrosis 1 and Ishak fibrosis 3.
Conclusion : Steatosis is significantly more common in genotype 3, while other features do not show any
differences. The portal tracts show partial involvement because inflammatory cells tend to aggregate and form
lymphoid follicles. The most comparable fibrosis scores are Knodell fibrosis 1 and Ishak fibrosis 3.
Keywords : Steatosis, Pathology, HCV
