Transrectal Ultrasound (TRUS) Findings of the Prostate Gland in Late Onset Hypogonadism with Testosterone Supplementation in Correlation with Clinical Outcome
Sith Phongkitkarun MD*, Apinan Rassameepong MD*, Sompol Permpongkosol MD, PhD**, Mayureewan Taphey MD*, Bussanee Wibulpolprasert MD*
Affiliation : * Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand ** Department of Surgery, Faculty of Medicine, Ramathibodi Hospital Bangkok, Thailand
Objective : To determine the TRUS fi ndings of the prostate and correlation of ultrasound fi ndings with clinical outcomes in
late-onset hypogonadal (LOH) men with testosterone supplementation.
Material and Method: Between January 2007 and September 2010, TRUS fi ndings and clinical outcomes of 16 from
226 subjects were studied. The demographic data, ultrasound parameters as prostate volume and vascularity, and
clinical parameters were evaluated. Correlation between ultrasound and clinical parameters were analyzed using Pearson
correlation analysis.
Results : During mean time follow-up of 6.48 months, the volume of the central gland (CG) signifi cantly increased
(p = 0.02), the volume of the total gland (TG) increased, and the volume of the peripheral zone (PZ) slightly decreased.
The vascularity of the TG, CG, and PZ were signifi cantly increased. The periurethral region vascularity was not signifi cantly
increased (p = 0.06), whereas total serum testosterone, prostate specifi c antigen (PSA), and PSA density were increased.
The International Prostate Symptom Score (IPSS) was signifi cantly decreased (p < 0.001). There was a signifi cant correlation
between increased prostate volume and increased serum PSA.
Conclusion : Testosterone supplementation in LOH men was found to cause an increase in TG volume during the fi rst
six months. The preferentially increased CG volume and prostatic vascularity might be due to exogenous testosterone. The
authors observed a signifi cantly increased PSA with a strong correlation between serum PSA and prostate volume.
Keywords : Prostate, Transrectal ultrasound, Late onset hypogonadism, Testosterone supplementation
