Pre-Operative Prediction of Serum CA125 Level in Women with Ovarian Masses
Mongkol Benjapibal MD*, Chanon Neungton MD*
Affiliation : * Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Objective : To assess the accuracy of serum CA125 at the level of more than 35 U/mL in predicting ovarian
cancer, using histopathology as a gold standard.
Materials and Methods : Blood samples were obtained from 120 women with ovarian masses scheduled for
elective surgery at Siriraj Hospital between October 1, 2003 and August 31, 2004 and sent for the assay of
serum CA125 levels.
Results : Of the 120 women enrolled, ovarian cancer was found in 59 cases (49.2%) and benign ovarian mass
in 61 cases (50.8%). The sensitivity, specificity, and accuracy of serum CA125 at the cutoff level of 35 U/mL for
prediction of ovarian cancer were 83.1%, 39.3%, and 60.8%, respectively; with 57.0% positive predictive
value, 70.6% negative predictive value, 60.7% false positive rate, and 16.9% false negative rate.
Conclusion : As stand-alone modality, serum CA125 of more than 35 U/mL in predicting ovarian cancer
revealed modest diagnostic accuracy. There is a need to be careful for false positive in women at reproductive
age group and false negative results in early-stage disease or ovarian cancer with low level of serum CA125.
Keywords : Serum CA125, Ovarian mass, Ovarian cancer
