Secondary Vaginal Involvement Following Radical Surgical Treatment for a Stage I Ovarian Adenocarcinoma Arising in Mature Cystic Teratoma
Noppadol Larbcharoensub MD*, Arb-aroon Lertkhachonsuk MD**, Mana Rochanawutanon MD*
Affiliation : * Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok **Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok
Background : Vaginal carcinoma represents 1-2% of all gynecologic malignancies. Most cases reported
secondary involvement from adjacent organs including cervix, uterus, and colorectum. Vaginal involvement
from adenocarcinoma arising in mature cystic teratoma (MCT) has never been reported.
Case: A 29-year-old female presented with postcoital vaginal bleeding. She had had a history of right ovarian
adenocarcinoma arising in MCT, FIGO stage IC, for 18 months’ duration. Incisional biopsy of the vaginal
lesion revealed adenocarcinoma, morphologically and immunohistologically identical to the right oophorec-
tomized specimen. She received three courses of paclitaxel and carboplatin chemotherapy; however, she
developed massive right pleural effusion with superior vena cava syndrome and finally succumbed to the
disease, three months later.
Conclusion : Adenocarcinoma is rarely found in MCT. This is the first case of ovarian adenocarcinoma arising
in MCT with secondary vaginal involvement, presenting as postcoital vaginal bleeding.
Keywords : Adenocarcinoma, Malignant transformation, Mature cystic teratoma, Vaginal involvement, Ovary
