A Comparison of Propofol-LCT with Propofol-LCT/MCT on Pain of Injection
Petchara Sundarathiti MD*, Nuanjai Boonthom MD*, Theerawat Chalacheewa MD*, Porpimon Jommaroeng RN*, Wanadee Rungsithiwan RN*
Affiliation : * Department of Anesthesiology, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok
Background : Propofol-Lipuro 1% is consisting of long-chain triglycerides (LCT) and medium-chain
triglycerides (MCT) that have been reported to reduce injection pain.
Objective : To compare the incidence and intensity of injection pain with 1% Propofol-LCT with 1% Propofol-
LCT/MCT in female populations for minor surgery under total intravenous anesthesia (TIVA).
Materials and Methods : One hundred and ten female patients were double-blind randomized into two groups.
Group long-chain triglycerdes (L) received 1% propofol-LCT while group long-chain triglycerides/medium-
chain triglycerides (L/M) received 1% propofol-LCT/MCT. All patients received no benzodiazepine pre-
medication and fentanyl 1 µg/kg was given 3 minutes before propofol injection. The propofol 1 mg/kg was
manually injected at 0.5 mL/sec. The verbal rating score (VRS 0-10) was recorded on pain of injection. VRS >
4 indicates a significant response to pain.
Results : There was a significantly greater incidence and intensity of injection pain in group L compared with
group L/M (p < 0.001 and p = 0.013 respectively).
Conclusions : Propofol-LCT/MCT is superior to propofol-LCT on reducing pain of injection.
Keywords : Pain on injection, Propofol LCT/MCT, TIVA
