Prevalence of Mild Cognitive Impairment in Clinical Dimensions of Chronic Obstructive Pulmonary Disease (COPD)
Worawat Chumpangern, MD1, Wipa Reechaipichitkul, MD1, Panita Limpawattana, MD2, Apichart So-Ngern, MD3, Itthiphat Arunsurat, MD1, Pailin Ratanawatkul, MD1, Manchumad Manjavong, MD2
Affiliation : 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 2Division of Geriatrics, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 3Division of Sleep Medicine, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Background: Impairment of cognitive function is reported to be a significant comorbidity of Chronic Obstructive Pulmonary Disease, which can have a negative effect on clinical outcomes.
Objective: To investigate the prevalence of mild cognitive impairment (MCI) among Thai COPD patients and related factors.
Materials and Methods: The cross-sectional study enrolled severe COPD patients in outpatient units (COPD registry) between September 2022 and December 2023. To assess cognitive function, the Thai version of the Rowland Universal Dementia Assessment Scale (RUDAS-Thai) was performed. Descriptive statistics were used to analyze characteristic data. Univariate and multivariate analyses were used to evaluate the variables associated with cognitive impairment among participants.
Results: A total of 40 participants were recruited for the present study, with 92.5% identifying as male. The median age was 72 years (IQR 65 to 78). The median score on the COPD Assessment Test (CAT) was 9.95 (IQR 3.75 to 15). Additionally, 50% of the participants had a history of severe acute exacerbations in recent years. The prevalence of mild cognitive impairment (MCI) was 57%, with a median RUDAS-Thai score of 25 (IQR 24 to 27.25). There was a significant correlation between a history of severe acute exacerbations and MCI (OR 7.42, 95% CI 1.91 to 34.69). However, no correlation was found between symptom scores and lung function in patients with MCI.
Keywords : COPD; Mild cognitive impairment; Rowland Universal Dementia Assessment Scale (RUDAS)
