Cord Blood Collection for the National Cord Blood Bank
in Thailand
TEERA WACHARAPRECHANONT,MD*, RACHANEE 0-CHAROEN, MD**,
PREEDA V ANICHSETAKUL, MD***, DENNOPPORN SUDJAI, MD*,
PA WINEE KUPA T A WINTU, BSc**, PANYA SEKSARN, MD***,
PlYA RAT SAMRITPRADIT, MD*, DHIRAPHONGS CHAROENVIDHYA, MD*
Affiliation : *Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University,
**The National Blood Center, The Thai Red Cross Society,
***Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
AbstractUmbilical cord blood is an effective alternative source of hematopoietic stem cells trans
plantation in children and adolescents. However, the efficacy and safety of cord blood transplantation
correlates with the quantity and quality of cord blood. To evaluate the collection systems and process
ing of cord blood donations, a pilot research program to optimize recruitment, collection and process
ing of cord blood donations was developed. The present results showed that the quality of the cord
blood (volume, total white blood cells (WBC) count, CD34+ and sterility control) collected was satis
factory and discard rate of collecting units (24.2%) were comparable with data reported from other cord
blood banks. To find the optimal mode of collection, comparison of 3 cord blood collection methods
(Method 1 = Hanging method after delivering the placenta, Method 2 = Aspiration from in utero
=
placenta, Method 3 Aspiration from in utero placenta and Syringe-assisted aspiration) using the closed
system showed that method 3 was the best method but it required more trained personnel and
involved a complicated procedure. The National Cord Blood Bank started its activity in 2002 after
several years of pre-clinical studies. To date, a number of transplants using cord blood from related and
unrelated cord blood (first report in Thailand) donors have been successfully performed.
Keywords : Umbilical Cord Blood, Collection Methods, Cord Blood Bank, Hematopoietic Stem Cell,
Transplantation
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